Endocannabinoids have been shown to play a role in the circadian rhythm, therefore CBD is thought to have an effect on sleep. Basic research in humans showed an overall increase in the total amount of sleep with several sleep disorders
Several human studies have shown some positive results of CBD in anxiety conditions. The effect of CBD on the region of the brain primarily associated with emotional processes was studied in brain imaging studies and showed a decrease in activation in this part of the brain after administration of CBD.
The only FDA approved CBD medication for childhood seizures, Dravet and Lennox-Gastaut syndromes, is Epidiolex, which is a synthetic substance with a purity of 98% CBD and less than 0.15% THC. Difference to the over-the-counter (OTC) CBDs is that Epidiolex is showing the same content of CBD and dose in one unit to the other.